Have you used phone support or only online through the portal/email? If you havent phone supported, then that’s the way to go and have a rep remote in to have a look.
What about my other question re wrapper log errors?
What’s the cpu usage like when you get the issues? I would suggest turning on history for the cpu and memory utilisation system tags if they’re not already on.
To take thread dumps that have the cpu usage info for each thread, you need to use the scripting function. Have a look here Is anyone else having crippling issues after adding Perspective to projects? - #32 by nminchin for what I used. Note, these issues in my post weren’t only caused by perspective, but were caused by various other things as well, ultimately a culmination of years of building on and on, and not doing some rework of things that worked for a smaller project, but then became too inefficient for a larger system. (inexperience at the time was the main factor)