I have struggling with a similar issue here and on a couple of other threads. The only OPC client I can get to connect to the Ignition OPC Server is the Ignition OPC Client. I have tried from several OPC UA clients. My primary goal is to connect with Kollmorgen's AGV system manager, but their documentation and logging is very limited. I have since tried to connect with three other OPC UA clients. All of them give me the same error in Ignition:
org.eclipse.milo.opcua.stack.core.UaException: no matching endpoint found: transportProfile=TCP_UASC_UABINARY, endpointUrl=opc.tcp://IP.Address.Of.Server:62541, securityPolicy=None, securityMode=None
All of them are setup to use Basic256sha256 & SignAndEncrypt, but Ignition is not recognizing it. I am able to connect these clients to Kepware and their certificates have to be accepted in Kepware's configuration or they cannot connect.
With one client's configuration, I was able to trick it to say the endpoint included the /discovery. At that point the Ignition log recognized the client was using Basic256sha256 and SignAndEncrypt, but of course Ignition refused the connection because it was not the actual endpoint.
Bind Address is set to 0.0.0.0 and both IP addresses are included with the Endpoint Addresses. I have configured the Ignition OPC Client to connect on the same IP addresses on both localhost and remote machines.