A problem appears with using Ignition, a Pi-Hole, and Cisco AnyConnect

Good morning,

Does anyone know what Pi-Hole is blocking from Cisco AnyConnect when connecting to an Ignition server behind a VPN?

PC <–> Pi-Hole <–> Cisco AnyConnect <–> Ignition server

I can access other company files, not on the Ignition server but on Server2, so not sure what the deal is.

I can also access the Ignition server when I bypass Pi-Hole.

Any clues you can offer me are appreciated.