Hello Sylvain_Therrien,
As long as you are able to exclude installation folders, used ports, cache folders, and java processes from inspection then it should be fine.
Our recommended port references that you should exclude - Gateway Port Reference - Ignition User Manual 8.1 - Ignition Documentation
Our typical install directory - C:\Program Files\Inductive Automation\Ignition
(Mainly for Vision Clients) Our cached folders - C:\Users\{username}\.ignition
If you require more aggressive AV rules, you can follow the forum here for specific directories to whitelist Real-time anti-virus scanners