I have no idea, but I edited the title for something that might catch the eye of someone who knows.
In the future, try to find a title that describes the issue, because pretty much everything people ask here is because of a "customer requirement".
Sounds like the customer wants kiosk mode, but only sometimes. I don't know if that is possible (to make kiosk mode conditional). This isn't really an Ignition issue, but a Windows issue, as Windows ultimately controls what is possible. (And outside of kiosk mode, I don't think you can block security-related key sequences like Ctrl-Alt-Del.)
If you want to venture beyond Ignition and hack something together, you might try playing with AutoHotKey to enable/disable certain keyboard keys, and use a script in Vision to start/stop the AHK script. I've never tried it so can't guarantee anything but might try some searching on the AHK forums.