Ignition connection to Kepware?

Can Ignition connect to Kepware if its in a different network?

For example if i have Kepware in my OT Zone and Ignition in my DMZ zone will i be able to connect to it? Or would i need Ignition in the OT Zone as well in this case?

Depends on your firewall, but should work. Note that Ignition generally should be in your OT zone if it is talking directly to other devices, or is participating in machine control (in the seconds to minutes timeframe).