OPC UA (KepserverEX) suddenly disconnect and can't reconnect

My KepserverEX suddenly disconnects and shows “Connection attempt to runtime failed” in the event log. Then it timed out and gave me a dialog box asking if I wanted to work offline.
After that I tried to restart the KepserverEX server and it eventually recovered. I tried tracing to the Threads Log and it displayed the following message before finally OPC could not connect:

Does anyone know the cause of this issue and how to resolve it?