Yes, plcsim is not meant to be used as a Software PLC of to be connected online. NETtoPlcsim is a hack to avoid that limitation.
There is PlcSim Advanced that simulates the onboard OPC-UA Server.
We are using 8.1.24 Siemens module to talk to S7-400 via PLC Sim. Very odd string tag behavior. We have Ignition and Wonderware Intouch running in parallel and the string values are not the same between systems even though the point to same memory address in PLC. Any ideas?