System.gui functions vs Layout settings

If I’m going to be moving components around with the system.gui.moveComponent and system.gui.resizeComponent what is the best layout setting? Is it possible for the two to cause conflicting behavior?

You can use any layout setting you want, but you’re probably going to be best off with using anchored top-left. This gives you the advantage of being able to get back proper coords when addressing a components x and y position in code.