Upgrade from 8.0.16 to 8.1.10 - Any concerns?

Looks like I am finally getting a client to consider an upgrade from 8.0.16 to 8.1.10.
I did quick search but was unable to get a sense of any issues for this upgrade.
Does anyone have any input for this upgrade with regards to issues, considerations to prevent issues, and the like?
Thanks!

There’s one issue with history that may or may not be a problem; it may be worth postponing an upgrade to 8.1.11 for that:

8.1.11 final release is projected for the first half of October, but that’s not a guarantee.

I’m not aware of anything else particularly major.

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Thanks Paul!
This customer is in a regulated environment, so it could be the middle of Oct before we get the go ahead, so that information is helpful.