Working Directory on second hard drive

Is it possible to install ignition on C drive but have it use E as the working Directory?

Especially for the store and forward.

Not within Ignition (why not just install the program into E:/ directly?) but if you want the data stored “remotely” you could use symlinks - a built in feature to every modern OS. The folder will still “appear” to be in the C drive, but the actual physical location of the data will be the remote drive.